This study investigates the influence of depressive symptoms, menopause- related physiological and psychological changes, and the presence of social support networks on the psychological well-being of women undergoing menopause. Recognizing menopause as a complex biopsychosocial transition, the research utilizes a quantitative, cross-sectional approach with standardized instruments to assess the variables among a purposively selected sample. Results indicate a significant negative correlation between depressive symptoms and psychological well-being, while strong social support networks demonstrate a buffering effect against distress. Menopause symptoms were also found to adversely affect well-being, albeit to a slightly lesser extent than depressive symptoms. The findings underscore the importance of a holistic framework in mental health support for menopausal women, emphasizing early screening and interventions tailored toward emotional, physiological, and social dimensions of the menopausal experience.